Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.

Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.

Tetrahedron also publishes thematic collections of papers as special issues and 'Reports', commissioned in-depth reviews providing a comprehensive overview of a research area.